Menatalla M. Elhindawy
Masnoura University, Egypt
Title: Biological impact of Curcumin on tongue ulcer healing in induced diabetic rats q
Biography
Biography: Menatalla M. Elhindawy
Abstract
Curcumin is a popular traditional medicine was first used in Indian and traditional Chinese medicine; it has a wide range of beneficial properties, including anti-inflammatory, antioxidant, chemo-preventive and chemotherapeutic activity. It can modulate growth factors and their signaling pathways; trasnforming growth facotr β1 (TGF-β1), platelet-derived growth
factor, insulin-like growth factor and colony-stimulating factors.The presence of TGF- β in the granulation tissue is of a great importance for efficient healing, since it was shown to stimulate angiogenesis, fibroblast proliferation, myofibroblast differentiation, and matrix deposition. Growth factors levels are affected in diabetes meletus; TGF- β levels within the wound fluid from diabetic rats were diminished and normal elevation of TGF- β in acute wound was absent in diabetic patients. oral administration curcumin increase the endogenous biosynthesis of TGF-β resulting in increased migration of epithelial cells; which lead to smaller ulcer size in the first 9 days.